How does chloroquine with proguanil prevent malaria? The older regimen

What was chloroquine with proguanil used for?

Chloroquine and proguanil were used together as an older malaria-prevention regimen. This is different from atovaquone/proguanil, the combination commonly associated with Malarone. Similar ingredient names do not make the products interchangeable.

An old travel guide or leftover travel pack is not evidence of a suitable preventive medicine for a new trip.

What current UK guidance says

The UKHSA 2026 chemoprophylaxis guidance states that Paludrine, the standalone proguanil product, and the Paludrine/Avloclor travel pack have been discontinued in the UK. It distinguishes these from atovaquone/proguanil supplies.

NaTHNaC's supply guidance also identifies discontinued products and directs readers to country-specific recommendations.

These are UK statements. They do not establish every country's present supply or prescribing rules. A pharmacist or travel-medicine clinician must check the actual product and local position.

Why the destination matters

Chloroquine resistance limits where a chloroquine-based approach can be used. A broad reference to Central America, the Caribbean or the Middle East is insufficient: risk and resistance differ within countries and change over time.

The CDC Yellow Book 2026 recommends reviewing the itinerary and current destination information. A clinician may choose another regimen, or determine that tablets are not recommended for a particular itinerary.

This article intentionally does not reproduce the old combination's tablet schedule. Historical doses cannot establish that it remains an appropriate or obtainable option.

Questions to bring to a travel appointment

1. Which towns or rural areas will I visit, and on what dates?
2. Is preventive medication recommended for those locations now?
3. Which actual medicine and presentation are available locally?
4. Do pregnancy, previous reactions, health conditions or current medicines change the choice?
5. What is the written plan for missed doses or illness abroad?

A recommendation made years ago should be reassessed for the new journey.

Prevention and urgent care

Use recommended mosquito-bite precautions alongside any prescribed preventive medicine. Fever during or after travel to a malaria-risk area needs immediate medical assessment; explain where and when you travelled.

See how independent online assessment works. Prescrivia is a technology intermediary, not a travel clinic or medicine seller. Independent clinicians decide suitability. No specific regimen, access or protection is guaranteed.

General information only, not medical advice. Follow the leaflet for your actual product and discuss decisions with a qualified clinician. See the current clinical, legal and language review statuses for this edition.

Sources

• UKHSA 2026 guidance: discontinuation of standalone proguanil and the travel pack in the UK, resistance limits and distinct antimalarial formulations.
• NaTHNaC supply guidance lists discontinued antimalarial products and directs users to country-specific alternatives.
• CDC Yellow Book 2026: itinerary-specific prevention, resistance, bite precautions and urgent fever assessment.

Sources checked online on 6 October 2026. Country-specific guidance does not establish availability or prescribing rules throughout Europe.