Cialis (Tadalafil)

O que é Cialis?

Cialis (tadalafil) is a receita médica-only oral medicamento approved by the Agência Europeia de Medicamentos (EMA) for the tratamento of erectile dysfunction (ED) in adult men. It is also approved for the tratamento of signs and symptoms of benign prostatic hyperplasia (BPH), and as a combination therapy for men who have both ED and BPH.

Tadalafil belongs to the same class of medicamentos as sildenafil (Viagra) and vardenafil (Levitra) — phosphodiesterase type 5 (PDE5) inhibitors — but is distinguished by its markedly longer duration of action of up to 36 hours per dose.

Como funciona Cialis work?

Like all PDE5 inhibitors, tadalafil works by blocking the enzyme phosphodiesterase type 5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP) in penile smooth muscle tissue.

During sexual stimulation, nitric oxide is released in the erectile tissue of the penis. This triggers a biochemical cascade that produces cGMP, which relaxes vascular smooth muscle, increases blood flow into the corpora cavernosa, and produces an erection. In men with erectile dysfunction, PDE5 degrades cGMP too rapidly, impairing this process.

By inhibiting PDE5, tadalafil allows cGMP to remain at higher concentrations for longer, supporting normal erectile function in response to sexual stimulation.

Tadalafil does not produce an erection in the absence of sexual stimulation. The medicamento supports — but does not replace — the physiological response to arousal.

For benign prostatic hyperplasia, tadalafil relaxes smooth muscle in the prostate, bladder, and bladder neck, reducing lower urinary tract symptoms such as difficulty urinating, weak stream, and urinary frequency.

Para quem é Cialis for?

Cialis is indicated for:

• Adult men with erectile dysfunction: Men who experience persistent difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity.
• Adult men with benign prostatic hyperplasia (BPH): Men with symptoms of an enlarged prostate, including urinary hesitancy, weak urine flow, incomplete bladder emptying, and nocturia.
• Adult men with both ED and BPH: The 5 mg daily dose is specifically approved for this combined indication.

Cialis is not appropriate for all men. A medical assessment is required to determine clinical suitability. It is contraindicated in men who:

• Take nitrate medicamentos in any form
• Have severe cardiovascular disease
• Have severe hepatic impairment
• Have had a recent stroke or myocardial infarction
• Have hypotension (blood pressure below 90/50 mmHg)

Dosagem

Cialis is available in two distinct dosing regimens:

On-demand dosing (for sexual activity)

Dose	Details
10 mg	Standard starting dose, taken 30 minutes before sexual activity
20 mg	If 10 mg is well-tolerated but insufficiently effective

On-demand doses are effective for up to 36 hours. Only one dose should be taken in a 24-hour period.

Daily dosing (continuous effect)

Dose	Typical Use
2.5 mg once daily	Starting dose for daily regimen
5 mg once daily	For ED, BPH, or both; if 2.5 mg is insufficient

Daily tadalafil maintains a stable concentration of the medicamento in the bloodstream, removing the need to plan around dosing. It is suitable for men who have sexual activity more than twice per week or who prefer spontaneous activity.

Food and drink: Unlike sildenafil, tadalafil absorption is not significantly affected by food or moderate alcohol consumption.

Efeitos secundários

As with all medicamentos, Cialis may cause efeito secundários.

Efeitos secundários comuns (podem afetar mais de 1 em 10 pessoas)

• Headache
• Dyspepsia (indigestion, heartburn)
• Back pain
• Myalgia (muscle aches)
• Flushing (facial warmth and redness)
• Nasal congestion

Back pain and myalgia are more commonly reported with tadalafil than with sildenafil or vardenafil, and typically resolve within 48 hours without intervention.

Menos comuns efeito secundários (podem afetar até 1 em 10 pessoas)

• Dizziness
• Blurred vision
• Nasal congestion or rhinitis

Efeitos secundários graves — procure assistência médica imediata

• Priapism: A persistent erection unrelated to sexual stimulation lasting more than 4 hours is a medical emergency. Immediate medical tratamento is required to prevent permanent injury.
• Sudden vision loss: Rare cases of NAION have been reported. Discontinue immediately and seek urgent medical care.
• Sudden hearing loss: Stop tratamento and contact a médico immediately.
• Severe hypotension: Risk is substantially increased if tadalafil is combined with nitrates. This combination is contraindicated.

Refer to the EMA-approved product information for a complete list of efeito secundários.

Cialis vs alternativas

All four PDE5 inhibitors listed below are EMA-approved for erectile dysfunction. This table is provided for informational purposes only. Individual suitability must be assessed by a qualified médico.

Medicine	Active Ingredient	Onset	Duration	Dosing
Cialis	Tadalafil	30–60 min	Up to 36 hours	On demand or daily
Viagra	Sildenafil Citrate	30–60 min	4–6 hours	On demand
Levitra	Vardenafil	25–60 min	4–5 hours	On demand
Generic Viagra	Sildenafil	30–60 min	4–6 hours	On demand

Key differences:

• Cialis vs Viagra: The most clinically significant difference is duration. Tadalafil remains effective for up to 36 hours versus 4–6 hours for sildenafil. Cialis is also less affected by food and is the only PDE5 inhibitor approved for BPH. Sildenafil is available at lower starting prices and has a longer post-market clinical history.
• Cialis vs Levitra: Both have similar onset profiles, but tadalafil’s markedly longer duration provides a larger window for spontaneous sexual activity. Levitra may have a slight edge in onset speed for some pacientes.
• Daily Cialis: This is a unique feature of tadalafil — no other PDE5 inhibitor is licensed for continuous daily use at a therapeutic dose in Europe. Daily dosing eliminates the need to time comprimido-taking around sexual activity.

Como aceder a Cialis online na Europa

Cialis is a medicamento sujeito a receita médica (POM) in all estados-membros da UE. A valid receita médica from a licensed medical professional is required before it can be legally dispensed.

Prescrivia operates as a technology intermediary: we do not prescribe medicamentos, employ médicos, or sell medicamentos. Our platform connects pacientes with independent EU-registered médicos who can conduct confidential online health assessments.

The process works as follows:

1. Complete uma avaliação de saúde: Answer structured health questions covering your medical history, current medications, urinary symptoms, and relevant lifestyle factors.
2. Avaliação médica: An independent EU-registered médico reviews your assessment. If tadalafil is clinically appropriate — either on-demand or daily — they may issue a receita médica. If it is not appropriate, the médico will explain why.
3. Receita e dispensa: If a receita médica is issued, it is sent to a licensed EU farmácia partner, which dispenses and ships the medicamento to you.

Important: A Prescrivia não garante that a receita médica will be issued. All prescribing decisions are made independently by qualified medical professionals.

Informação de segurança importante

Não utilize Cialis if you:

• Take any form of nitrate medicamento (including glyceryl trinitrate, isosorbide mononitrate, isosorbide dinitrate, or nitrate-containing recreational drugs)
• Have severe cardiovascular disease or have been told to avoid sexual activity for cardiac reasons
• Have severe liver impairment (Child-Pugh Class C)
• Have blood pressure below 90/50 mmHg
• Are allergic to tadalafil or any ingredient in Cialis

Informe o seu médico before starting Cialis if you have:

• Any history of heart disease, heart attack, or stroke
• Severe kidney disease
• Retinitis pigmentosa or a history of NAION
• Peyronie’s disease or other penile abnormality
• Sickle cell anaemia, multiple myeloma, or leukaemia
• BPH treated with alpha-blockers (combination requires careful dose management)

Interações medicamentosas: Tadalafil has significant interactions with nitrates (absolutely contraindicated), alpha-blockers (risk of hypotension — dose adjustment required), antihypertensives, CYP3A4 inhibitors (including ritonavir, ketoconazole, and itraconazole), and rifampicin. Always disclose all current medications to the reviewing médico.

Fontes

Medical information on this page is based on the following sources:

• Agência Europeia de Medicamentos (EMA). Cialis (tadalafil) — Summary of Product Characteristics. Available at: ema.europa.eu
• Agência Europeia de Medicamentos (EMA). Assessment report: Cialis. EMEA/H/C/000436.
• Organização Mundial da Saúde (WHO). Sexual health — Fact sheet. who.int
• Brock GB, et al. Efficacy and safety of tadalafil for the tratamento of erectile dysfunction: results of integrated analyses. J Urol. 2002;168:1332-1336.

This content is reviewed periodically to reflect updated clinical guidance. It is provided for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for advice relevant to your individual health circumstances.