Ce este Cialis (Tadalafil)?
Cialis (tadalafil) is a prescription-only oral medicine approved by the European Medicines Agency (EMA) for the treatment of erectile dysfunction (ED) in adult men. It is also approved for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH), and as a combination therapy for men who have both ED and BPH.
Tadalafil belongs to the same class of medicines as sildenafil (Viagra) and vardenafil (Levitra) — phosphodiesterase type 5 (PDE5) inhibitors — but is distinguished by its markedly longer duration of action of up to 36 hours per dose.
Cum funcționează Cialis (Tadalafil)?
Like all PDE5 inhibitors, tadalafil works by blocking the enzyme phosphodiesterase type 5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP) in penile smooth muscle tissue.
During sexual stimulation, nitric oxide is released in the erectile tissue of the penis. This triggers a biochemical cascade that produces cGMP, which relaxes vascular smooth muscle, increases blood flow into the corpora cavernosa, and produces an erection. In men with erectile dysfunction, PDE5 degrades cGMP too rapidly, impairing this process.
By inhibiting PDE5, tadalafil allows cGMP to remain at higher concentrations for longer, supporting normal erectile function in response to sexual stimulation.
Tadalafil does not produce an erection in the absence of sexual stimulation. The medicine supports — but does not replace — the physiological response to arousal.
For benign prostatic hyperplasia, tadalafil relaxes smooth muscle in the prostate, bladder, and bladder neck, reducing lower urinary tract symptoms such as difficulty urinating, weak stream, and urinary frequency.
Pentru cine este indicat Cialis (Tadalafil)?
Cialis is indicated for:
- Adult men with erectile dysfunction: Men who experience persistent difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity.
- Adult men with benign prostatic hyperplasia (BPH): Men with symptoms of an enlarged prostate, including urinary hesitancy, weak urine flow, incomplete bladder emptying, and nocturia.
- Adult men with both ED and BPH: The 5 mg daily dose is specifically approved for this combined indication.
Cialis is not appropriate for all men. A medical assessment is required to determine clinical suitability. It is contraindicated in men who:
- Take nitrate medicines in any form
- Have severe cardiovascular disease
- Have severe hepatic impairment
- Have had a recent stroke or myocardial infarction
- Have hypotension (blood pressure below 90/50 mmHg)
Dozaj
Cialis is available in two distinct dosing regimens:
On-demand dosing (for sexual activity)
| Dose | Details |
|---|---|
| 10 mg | Standard starting dose, taken 30 minutes before sexual activity |
| 20 mg | If 10 mg is well-tolerated but insufficiently effective |
On-demand doses are effective for up to 36 hours. Only one dose should be taken in a 24-hour period.
Daily dosing (continuous effect)
| Dose | Typical Use |
|---|---|
| 2.5 mg once daily | Starting dose for daily regimen |
| 5 mg once daily | For ED, BPH, or both; if 2.5 mg is insufficient |
Daily tadalafil maintains a stable concentration of the medicine in the bloodstream, removing the need to plan around dosing. It is suitable for men who have sexual activity more than twice per week or who prefer spontaneous activity.
Food and drink: Unlike sildenafil, tadalafil absorption is not significantly affected by food or moderate alcohol consumption.
Efecte secundare
As with all medicines, Cialis may cause side effects.
Efecte secundare frecvente (pot afecta mai mult de 1 din 10 persoane)
- Headache
- Dyspepsia (indigestion, heartburn)
- Back pain
- Myalgia (muscle aches)
- Flushing (facial warmth and redness)
- Nasal congestion
Back pain and myalgia are more commonly reported with tadalafil than with sildenafil or vardenafil, and typically resolve within 48 hours without intervention.
Less common side effects (may affect up to 1 in 10 people)
- Dizziness
- Blurred vision
- Nasal congestion or rhinitis
Serious side effects — seek immediate medical attention
- Priapism: A persistent erection unrelated to sexual stimulation lasting more than 4 hours is a medical emergency. Immediate medical treatment is required to prevent permanent injury.
- Sudden vision loss: Rare cases of NAION have been reported. Discontinue immediately and seek urgent medical care.
- Sudden hearing loss: Stop treatment and contact a doctor immediately.
- Severe hypotension: Risk is substantially increased if tadalafil is combined with nitrates. This combination is contraindicated.
Refer to the EMA-approved product information for a complete list of side effects.
Cialis (Tadalafil) vs alternative
All four PDE5 inhibitors listed below are EMA-approved for erectile dysfunction. This table is provided for informational purposes only. Individual suitability must be assessed by a qualified doctor.
| Medicine | Active Ingredient | Onset | Duration | Dosing |
|---|---|---|---|---|
| Cialis | Tadalafil | 30–60 min | Up to 36 hours | On demand or daily |
| Viagra | Sildenafil Citrate | 30–60 min | 4–6 hours | On demand |
| Levitra | Vardenafil | 25–60 min | 4–5 hours | On demand |
| Generic Viagra | Sildenafil | 30–60 min | 4–6 hours | On demand |
Diferențe principale:
- Cialis vs Viagra: The most clinically significant difference is duration. Tadalafil remains effective for up to 36 hours versus 4–6 hours for sildenafil. Cialis is also less affected by food and is the only PDE5 inhibitor approved for BPH. Sildenafil is available at lower starting prices and has a longer post-market clinical history.
- Cialis vs Levitra: Both have similar onset profiles, but tadalafil’s markedly longer duration provides a larger window for spontaneous sexual activity. Levitra may have a slight edge in onset speed for some patients.
- Daily Cialis: This is a unique feature of tadalafil — no other PDE5 inhibitor is licensed for continuous daily use at a therapeutic dose in Europe. Daily dosing eliminates the need to time tablet-taking around sexual activity.
Cum puteți obține Cialis (Tadalafil) online în Europa
Cialis is a prescription-only medicine (POM) in all EU member states. A valid prescription from a licensed medical professional is required before it can be legally dispensed.
Prescrivia funcționează ca intermediar tehnologic: nu prescriem medicamente, nu angajăm medici și nu vindem medicamente. Platforma noastră conectează pacienții cu medici independenți înregistrați în UE, care pot efectua evaluări medicale online confidențiale.
Procesul este următorul:
- Completați un chestionar medical: Answer structured health questions covering your medical history, current medications, urinary symptoms, and relevant lifestyle factors.
- Evaluarea medicului: An independent EU-registered doctor reviews your assessment. If tadalafil is clinically appropriate — either on-demand or daily — they may issue a prescription. If it is not appropriate, the doctor will explain why.
- Prescripție și livrare: If a prescription is issued, it is sent to a licensed EU pharmacy partner, which dispenses and ships the medicine to you.
Important: Prescrivia does not guarantee that a prescription will be issued. All prescribing decisions are made independently by qualified medical professionals.
Informații importante privind siguranța
Nu utilizați Cialis (Tadalafil) dacă:
- Take any form of nitrate medicine (including glyceryl trinitrate, isosorbide mononitrate, isosorbide dinitrate, or nitrate-containing recreational drugs)
- Have severe cardiovascular disease or have been told to avoid sexual activity for cardiac reasons
- Have severe liver impairment (Child-Pugh Class C)
- Have blood pressure below 90/50 mmHg
- Are allergic to tadalafil or any ingredient in Cialis
Informați medicul dumneavoastră înainte de a începe Cialis (Tadalafil) dacă aveți:
- Any history of heart disease, heart attack, or stroke
- Severe kidney disease
- Retinitis pigmentosa or a history of NAION
- Peyronie’s disease or other penile abnormality
- Sickle cell anaemia, multiple myeloma, or leukaemia
- BPH treated with alpha-blockers (combination requires careful dose management)
Interacțiuni medicamentoase: Tadalafil has significant interactions with nitrates (absolutely contraindicated), alpha-blockers (risk of hypotension — dose adjustment required), antihypertensives, CYP3A4 inhibitors (including ritonavir, ketoconazole, and itraconazole), and rifampicin. Always disclose all current medications to the reviewing doctor.
Surse
Informațiile medicale de pe această pagină se bazează pe următoarele surse:
- European Medicines Agency (EMA). Cialis (tadalafil) — Summary of Product Characteristics. Available at: ema.europa.eu
- European Medicines Agency (EMA). Assessment report: Cialis. EMEA/H/C/000436.
- World Health Organization (WHO). Sexual health — Fact sheet. who.int
- Brock GB, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002;168:1332-1336.
Acest conținut este revizuit periodic pentru a reflecta ghidurile clinice actualizate. Este furnizat exclusiv în scop informativ și nu constituie sfat medical. Consultați întotdeauna un profesionist medical calificat pentru sfaturi relevante pentru circumstanțele dumneavoastră individuale de sănătate.
Frequently asked questions
- Pentru ce se utilizează Cialis (Tadalafil)?
- Cialis (tadalafil) is approved by the European Medicines Agency (EMA) for two indications: erectile dysfunction (ED) in adult men, and the signs and symptoms of benign prostatic hyperplasia (BPH) — an enlarged prostate — in adult men. It is the only PDE5 inhibitor approved for both conditions.
- Cât timp does Cialis last?
- Cialis has a significantly longer duration of action than other PDE5 inhibitors. A single on-demand dose (10 mg or 20 mg) can remain effective for up to 36 hours, giving patients a wider window for spontaneous sexual activity compared to sildenafil or vardenafil. This is why Cialis is sometimes called the 'weekend pill'.
- Care este diferența between Cialis on demand and Cialis daily?
- On-demand Cialis (10 mg or 20 mg) is taken 30 minutes before anticipated sexual activity and provides up to 36 hours of effectiveness. Daily Cialis (2.5 mg or 5 mg) is taken once every day at the same time, maintaining continuous low-level tadalafil in the bloodstream. Daily dosing is suitable for men who prefer not to plan around tablet-taking or who have sexual activity more than twice a week.
- Pot obține Cialis (Tadalafil) online în Europa?
- Puteți accesa acest medicament prin platforme intermediare online care vă conectează cu medici independenți înregistrați în UE. După completarea unui chestionar medical confidențial, un medic va evalua dacă medicamentul este adecvat clinic pentru dumneavoastră.
- Is Cialis affected by food or alcohol?
- Unlike sildenafil, tadalafil can be taken with or without food, including high-fat meals, without a clinically meaningful impact on its absorption or onset. Moderate alcohol consumption (up to 3 units) does not significantly reduce tadalafil's effectiveness, though excessive alcohol can worsen ED and increase the risk of side effects such as low blood pressure and dizziness.
Tratamente
Prescrivia este doar o platformă intermediară. Nu furnizăm servicii medicale, nu prescriem tratamente și nu eliberăm medicamente. Toate deciziile medicale sunt luate de medici independenți înregistrați în UE. Toate medicamentele sunt eliberate de farmacii licențiate din UE. Această platformă facilitează legătura între pacienți și furnizorii de servicii medicale.